Stephan Krähenbühl Selected Research

Dipyrone (Metamizole)

10/2020	Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.
10/2019	Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients.
10/2019	Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes.
1/2019	Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.
1/2019	Acute Liver Failure in a Patient Treated With Metamizole.
5/2017	Leucopenia associated with metamizole: a case-control study.
1/2017	Leucopenia associated with metamizole: a case-control study.
2/2015	Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports.

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Stephan Krähenbühl Research Topics

Disease

11	Muscular Diseases (Myopathy) 10/2021 - 06/2004
10	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 12/2011
9	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 04/2003
9	Drug-Related Side Effects and Adverse Reactions 01/2021 - 01/2005
8	Myotoxicity 10/2021 - 08/2015
7	Hepatocellular Carcinoma (Hepatoma) 10/2021 - 10/2014
7	Neoplasms (Cancer) 01/2020 - 10/2007
7	Necrosis 01/2018 - 04/2005
6	Agranulocytosis (Granulocytopenia) 10/2020 - 06/2013
5	Fibrosis (Cirrhosis) 01/2022 - 01/2009
5	Neutropenia 10/2020 - 06/2013
5	Fatty Liver 01/2018 - 01/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 12/2011
4	Insulin Resistance 05/2021 - 10/2009
4	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2010
4	Body Weight (Weight, Body) 11/2018 - 02/2006
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 10/2017
3	Muscular Atrophy (Muscle Atrophy) 01/2020 - 05/2017
3	Chemical and Drug Induced Liver Injury 01/2019 - 05/2013
3	Acute Liver Failure (Fulminant Hepatic Failure) 01/2019 - 01/2003
3	Liver Failure 01/2018 - 01/2003
3	Infections 11/2017 - 01/2017
3	Hypersensitivity (Allergy) 05/2017 - 05/2002
3	Atrophy 01/2016 - 08/2015
3	Type 2 Diabetes Mellitus (MODY) 06/2010 - 07/2006
3	Liver Diseases (Liver Disease) 01/2009 - 01/2005
3	Cholestasis 01/2005 - 01/2002
2	Cardiotoxicity 02/2022 - 10/2019
2	Sleep Initiation and Maintenance Disorders (Insomnia) 10/2021 - 08/2011
2	Genetic Predisposition to Disease (Genetic Predisposition) 10/2020 - 01/2019
2	Scabies (Sarcoptic Mange) 01/2020 - 01/2019
2	Immune System Diseases (Immune Disorders) 01/2020 - 10/2019
2	Malaria 01/2020 - 01/2019
2	Pain (Aches) 01/2020 - 07/2004
2	Pruritus (Itching) 01/2019 - 01/2011
2	Hepatitis C 05/2017 - 01/2017
2	Hyperbilirubinemia 05/2016 - 10/2014
2	Schizophrenia (Dementia Praecox) 12/2015 - 09/2010
2	Pulmonary Arterial Hypertension 03/2015 - 02/2008
2	Fever (Fevers) 01/2015 - 05/2002
2	Seizures (Absence Seizure) 08/2008 - 03/2008
2	Hemorrhage 12/2007 - 06/2005
2	Heart Failure 12/2007 - 01/2006

Drug/Important Bio-Agent (IBA)

20	Pharmaceutical PreparationsIBA 01/2019 - 05/2002
17	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2021 - 06/2004
11	Simvastatin (Zocor)FDA LinkGeneric 10/2021 - 06/2004
8	Dipyrone (Metamizole)IBA 10/2020 - 02/2015
6	Carnitine (L-Carnitine)FDA LinkGeneric 01/2016 - 01/2003
5	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2010
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 11/2002
4	Cytochrome P-450 CYP3AIBA 01/2022 - 02/2011
4	Glucose (Dextrose)FDA LinkGeneric 05/2021 - 10/2009
4	Insulin (Novolin)FDA Link 01/2019 - 06/2004
4	Amiodarone (Amiodarona)FDA LinkGeneric 02/2011 - 06/2004
3	EnzymesIBA 02/2022 - 01/2021
3	Sorafenib (BAY 43-9006)FDA Link 02/2022 - 04/2017
3	Tyrosine Kinase InhibitorsIBA 02/2022 - 04/2017
3	Methotrexate (Mexate)FDA LinkGeneric 09/2021 - 02/2012
3	Ivermectin (Mectizan)FDA Link 01/2020 - 01/2019
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 01/2003
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2017
3	Cytochromes c (Cytochrome c)IBA 01/2018 - 02/2011
3	CholesterolIBA 01/2015 - 11/2009
3	Antipsychotic Agents (Antipsychotics)IBA 09/2010 - 08/2008
3	GlycogenIBA 01/2008 - 01/2002
3	AnticoagulantsIBA 12/2007 - 06/2005
2	Imatinib Mesylate (Gleevec)FDA Link 02/2022 - 01/2020
2	Metoprolol (Toprol-XL)FDA LinkGeneric 01/2022 - 06/2004
2	Midazolam (Versed)FDA LinkGeneric 01/2022 - 02/2008
2	Mechanistic Target of Rapamycin Complex 2IBA 10/2021 - 01/2020
2	LDL CholesterolIBA 10/2021 - 01/2021
2	LipidsIBA 01/2021 - 11/2009
2	Analgesics (Analgesic Drugs)IBA 10/2020 - 01/2019
2	Messenger RNA (mRNA)IBA 01/2020 - 01/2019
2	BenzbromaroneIBA 01/2020 - 04/2005
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2020 - 01/2019
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2020 - 10/2017
2	Sunitinib (Sutent)FDA Link 10/2019 - 11/2018
2	1- naphthalen- 2- yl- 2- pyrrolidin- 1- ylpentan- 1- oneIBA 03/2019 - 08/2011
2	Sympathomimetics (Sympathomimetic Amines)IBA 03/2019 - 08/2011
2	Oxycodone (Oxycontin)FDA LinkGeneric 01/2019 - 01/2011
2	Atorvastatin (Lipitor)FDA Link 01/2019 - 01/2016
2	Tolcapone (Tasmar)FDA Link 01/2018 - 08/2017
2	Cytostatic AgentsIBA 05/2017 - 01/2017
2	Ketoconazole (Nizoral)FDA LinkGeneric 01/2017 - 01/2011
2	Mitochondrial DNA (mtDNA)IBA 01/2016 - 03/2006
2	Allopurinol (Remid)FDA LinkGeneric 01/2016 - 01/2014
2	Transaminases (Aminotransferases)IBA 10/2014 - 09/2014
2	Propranolol (Inderal)FDA LinkGeneric 01/2014 - 07/2004
2	Metformin (Glucophage)FDA LinkGeneric 06/2010 - 11/2008
2	Estrogens (Estrogen)FDA Link 06/2010 - 11/2009
2	urotensin IIIBA 10/2009 - 09/2006
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2009 - 02/2008
2	BenzodiazepinesIBA 08/2008 - 01/2006
2	Phenytoin (Dilantin)FDA LinkGeneric 03/2008 - 02/2008
2	Carbamazepine (Tegretol)FDA LinkGeneric 02/2008 - 07/2004

Therapy/Procedure

8	Therapeutics 01/2020 - 06/2004
4	Polypharmacy 01/2019 - 01/2006
3	Mass Drug Administration 01/2020 - 01/2019
3	Drug Therapy (Chemotherapy) 12/2015 - 01/2006